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Hereditary cancer genetic testing menu

The overview below offers a quick glance at our comprehensive offerings for you and your patients.

Comprehensive Hereditary Cancer Panel

The Comprehensive Hereditary Cancer Panel includes 66 genes associated with a broad spectrum of hereditary cancers. This can include, but is not limited to, cancers of the breast, colon, endometrium, ovary, pancreas, prostate, rectum, neuroendocrine system, and other tissues. This panel would be used if the clinician desires comprehensive analysis of genes related to a variety of cancers containing clinically actionable genes as well as emerging genes.

Test name

Test code

GSP or CPT coding

FAQ

Comprehensive Hereditary Cancer Panel (66 genes)
Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

38600

For breast: 81432, 81433

For colon: 81435, 81436

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Guideline-Based Hereditary Cancer Panel

The Guideline-Based Hereditary Cancer Panel includes clinically actionable analysis of 32 genes including moderate to high risk to provide clinically actionable results that give you a clearer picture of your patient’s potential risk for hereditary cancers, including breast, colon, prostate, uterine, melanoma, and other hereditary cancers. This panel would be used if the clinician desires comprehensive analysis of genes related to more common cancers.

Test name

Test code

GSP or CPT coding

Comprehensive Hereditary Cancer Panel (66 genes) Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

38611

For breast: 81432, 81433

For colon: 81435, 81436

Sub-panels for hereditary cancers

The panels include genes selected by following medically accepted guidelines and can be collected using saliva, blood, or fibroblast.

Test name

Test code

GSP or CPT coding

FAQ

Hereditary Breast Cancer Panel (18 genes)
Tests for variants in 18 genes predominantly associated with cancers of the breast, prostate, and other tissues, including: ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53

38600

81432, 81433

 

Hereditary Colorectal Cancer Panel (20 genes)
Tests for variants in 20 genes associated with increased risk for colorectal cancer including: APC, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

38631

81435, 81436

 

Hereditary Endocrine Cancer Panel (12 genes)
Tests for variants in 12 genes associated with increased risk for paragangliomas, pheochromocytomas, and endocrine cancer: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

38641

81437, 81438

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BRCA Panel Plus (7 genes)
Detects variants in BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53

92587

81162, 81307, 81321, 81323, 81351, 81404, 81405, 81406, 81479

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Additional hereditary cancer risk tests

Certain things make it more likely that cancers in a family are caused by a hereditary cancer syndrome, such as:

  • Many cases of the same type of cancer (especially if it is an uncommon or rare type of cancer)
  • Cancers occurring at younger ages than usual (typically cancer in someone younger than 50 years old)
  • More than 1 type of cancer in a single person (such as a person with both breast and ovarian cancer)
  • Cancers occurring in both of a pair of organs (such as both eyes, both kidneys, or both breasts)
  • Cancer occurring in the sex not usually affected (such as breast cancer in a male)
  • Cancer occurring in multiple generations (such as in a parent, child, and grandchild)

Test name

Test code

GSP or CPT coding

FAQ

Lynch syndrome

Lynch Syndrome Panel (5 genes)
Detects pathogenic variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM (del/dup only) genes

91461

81295, 81297, 81292, 81294, 81298, 81300, 81317, 81319, 81403

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 Other cancer risks

Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU)
Detects variants in PTCH1 and SUFU

38651

81479

View

Tuberous Sclerosis Complex Panel (TSC1, TSC2)
Detects variants in TSC1 and TSC2

38661

81405, 81406 (x2), 81407

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Juvenile Polyposis Panel (BMPR1A, SMAD4)
Detects pathogenic and variants of unknown significance (VUS) in the BMPR1A and SMAD4 genes

94053

81405, 81406, 81479

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Single-site test

Single-site testing is available when there is a known variant in the family. This test is available for any of the 66 genes on our Comprehensive Hereditary Cancer Panel.

Test name

Test code

GSP or CPT coding

FAQ

Hereditary Cancer Single Site(s)
APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A (p16, p14), CHEK2, DICER1, EGFR, EPCAM, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

93945

Please call Genomic View Client Services 1.866.GENE.INFO (1.866.436.3463) for more information

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Single-gene test

We have added single-gene tests for specific instances when a patient’s personal and/or family history points to a specific gene instead of a broader evaluation.

Test name

Test code

GSP or CPT coding

FAQ

APC Sequencing and Deletion/Duplication

93797

81201, 81203

View

ATM Sequencing and Deletion/Duplication

38802

81408, 81479

View

BAP1 Sequencing and Deletion/Duplication

38803

81479

View

BLM Sequencing and Deletion/Duplication

38804

81479

View

CDH1 Sequencing and Deletion/Duplication

92568

81406, 81479

View

CDKN2A Sequencing and Deletion/Duplication

93939

81404, 81479

View

CHEK2 Sequencing and Deletion/Duplication

93940

81479

View

Lynch Syndrome, MSH2 Sequencing and Deletion/Duplication (Including EPCAM)

91471

81295, 81297, 81403

View

FH Gene Sequencing and Deletion/Duplication

38805

81405, 81479

View

FLCN Sequencing and Deletion/Duplication

38806

81479

View

HOXB13 Sequencing and Deletion/Duplication

38807

81479

View

MEN1 Sequencing and Deletion/Duplication

93942

81405, 81404

View

MITF Gene Analysis

38808

81479

View

Lynch Syndrome, MLH1 Sequencing and Deletion/Duplication

91460

81292, 81294

View

Lynch Syndrome, MSH6 Sequencing and Deletion/Duplication

91458

81298, 81300

View

MUTYH Sequencing and Deletion/Duplication

93944

81406, 81479

View

NF1 Sequencing and Deletion/Duplication

93941

81408, 81479

View

PALB2 Sequencing and Deletion/Duplication

92571

81307, 81479

View

Lynch Syndrome, PMS2 Sequencing and Deletion/Duplication

91457

81317, 81319

View

PTEN Sequencing and Deletion/Duplication

92566

81321, 81323

View

RET Sequencing and Deletion/Duplication

93796

81406, 81479

View

SMARCA4 Sequencing and Deletion/Duplication

38809

81479

View

STK11 Sequencing and Deletion/Duplication

92565

81405, 81404

View

Li-Fraumeni Syndrome, TP53 Sequencing and Deletion/Duplication

92560

81351, 81479

View

VHL Sequencing and Deletion/Duplication

93943

81404, 81403

View

Test codes may vary by location. Please contact your local laboratory for more information.

Components of panels may be ordered separately.

The CPT® codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Only a patient’s treating physician can make diagnoses, prognostic or treatment decisions based on the knowledge of the patient, history and clinical/educational experience. Quest lab testing provides information for the physician to use in helping make such decisions.