Skip to main content

Holiday schedule

Our Patient Service Centers will be closed on Thursday, November 28, 2024 in observance of Thanksgiving. Have a healthy, happy holiday.

Hide
Quest Diagnostics

Follicular Lymphoma, EZH2 Mutation, COBAS

Test code(s) 39928

The Follicular Lymphoma, EZH2 Mutation, COBAS test is a real-time, allele-specific PCR test approved by the US Food and Drug Administration (FDA) for the qualitative detection of common mutations in the enhancer of zeste 2 polycomb repressive complex 2 (EZH2) gene in patients with follicular lymphoma.1 Testing is performed on DNA extracted from formalin-fixed, paraffin-embedded (FFPE) follicular lymphoma tumor tissue and identifies the following variants: Y646N, Y646F or Y646X (Y646H, Y646S, or Y646C), A682G, and A692V.

Testing is performed on FFPE follicular lymphoma tumor tissue.

Results can be expected 7 days after specimen receipt.

Reference

  1. cobas® EZH2 Mutation Test. Package insert. Roche Diagnostics Inc; 2020.
  2. Bödör C, Grossmann V, Popov N, et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood. 2013;122(18):3165-3168. doi:10.1182/blood-2013-04-496893
  3. Morin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42(2):181-185. doi:10.1038/ng.518 TAZVERIK® (tazemetostat). Highlights of prescribing information. Epizyme Inc; 2020.
  4. TAZVERIK® (tazemetostat). Highlights of prescribing information. Epizyme Inc; 2020.

 

This FAQ is provided for informational purposes only and is not intended as medical advice. Test selection and interpretation, diagnosis, and patient management decisions should be based on the clinician’s education, clinical expertise, and assessment of the patient.


Document FAQS.263 Version: 0
Effective 06/14/2021 to present

Our company

Quest® is the brand name used for services offered by Quest Diagnostics Incorporated and its affiliated companies. Quest Diagnostics Incorporated and certain affiliates are CLIA certified laboratories that provide HIPAA covered services.  Other affiliates operated under the Quest® brand, such as Quest Consumer Inc., do not provide HIPAA covered services. 

 

Quest®, Quest Diagnostics®, any associated logos, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third-party marks—® and ™—are the property of their respective owners. © 2024 Quest Diagnostics Incorporated. All rights reserved. Image content features models and is intended for illustrative purposes only.